Particularly, as compared to the wounds stemming from the piercing of soft tissue, cartilage piercings (e.g., the auricle of the ear) have a greater predisposition to complications. pyogenes) (Lancefield Group A) are the most common pathogens causing these local infections. Among all these problems, local infection has been reported to be the most common type of piercing complication. As most of these piercings are not performed in clinical settings, 17–46% of the piercings lead to complications including infection, metal allergy, bleeding, and tissue scarring. The efficacy of the biopierces against Staphylococcus aureus, one of the most common piercing-site pathogens, was confirmed over two weeks using in vitro antimicrobial susceptibility testing.īody piercing has become very popular in the past two decades, and it has been reported that approximately 50% of millennials receive at least one non-earlobe piercing. Proton nuclear magnetic resonance ( 1H NMR) spectroscopy was used to confirm the complete removal of the solvent, and liquid chromatography high-resolution mass spectrometry (LC-HRMS) was used to confirm the structural integrity of mupirocin and to quantify the amount of the released drug over time. Biopierces were made using mupirocin loaded poly-lactic- co-glycolic acid (PLGA) biomaterial ink, and a low-temperature 3D printing technique was used to fabricate the biopierces. Therefore, it is imperative to develop alternative methods of piercing aftercare to prevent infection. Nearly 20% of all piercings lead to local infection. This “biopierce” will stay in human tissue following piercing, and will slowly release an antimicrobial agent to prevent infection while the wound heals. Herein, novel drug-eluting, bio-absorbable scaffold intended to cover piercing studs is introduced.
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